Description

trans-2-Fluoro-Cyclopropanecarboxylic Acid Ethyl Ester is a high-value fluorinated cyclopropane building block, a key intermediate in modern synthetic organic chemistry. Its unique structure, featuring a fluorine atom on the strained cyclopropane ring, is crucial for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. Its application extends to advanced material science for creating specialized polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of fluorinated drug candidates, including protease inhibitors, kinase inhibitors, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorocyclopropane moiety enhances efficacy and environmental profile.
• Material Science Research: Serves as a precursor for fluorinated monomers and liquid crystals, contributing to the development of polymers with specific optical or surface properties.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological systems and enzyme mechanisms.
• Asymmetric Synthesis Building Block: Utilized in stereoselective reactions to construct complex, chiral molecules for advanced chemical research.

Basic Information

Product Name	trans-2-Fluoro-Cyclopropanecarboxylic Acid Ethyl Ester
CAS No.	188428-48-0
Molecular Formula	C6H9FO2
Molecular Weight	132.13 g/mol
Synonyms	Ethyl trans-2-Fluorocyclopropanecarboxylate; trans-Ethyl 2-Fluorocyclopropanecarboxylate; 2-Fluorocyclopropanecarboxylic Acid Ethyl Ester (trans-); (1R,2S)- and (1S,2R)-2-Fluorocyclopropanecarboxylic Acid Ethyl Ester; Ethyl (1R,2S)-2-Fluorocyclopropanecarboxylate; Ethyl (1S,2R)-2-Fluorocyclopropanecarboxylate; 188428-48-0; FC-COOEt
EINECS	Contact for details

Quality Control

Our trans-2-Fluoro-Cyclopropanecarboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure high chemical and isomeric purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for critical research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.