Description

Voriconazole-D3 is a deuterated isotopologue of the potent antifungal agent Voriconazole, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is an essential reference standard and internal standard for the precise quantification and pharmacokinetic studies of Voriconazole in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in bioanalytical method development, drug metabolism research, and ensuring regulatory compliance for antifungal therapies.

Application

• Primary use as an Internal Standard for the accurate quantification of Voriconazole in bioanalytical assays (e.g., LC-MS/MS, HPLC).
• Reference Standard for method development, validation, and quality control in pharmaceutical analysis.
• Critical component in Pharmacokinetic and Metabolism Studies to track drug absorption, distribution, and excretion.
• Used in Doping Control and forensic analysis for the precise identification of Voriconazole.
• Essential for Clinical Research and therapeutic drug monitoring (TDM) programs.
• Supporting material for Regulatory Submissions to agencies like the FDA and EMA, requiring validated analytical methods.

Basic Information

Product Name	Voriconazole-D3
CAS No.	188416-29-7
Molecular Formula	C16H11D3F3N5O
Molecular Weight	352.33 g/mol
Synonyms	(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol-d3; Voriconazole (methyl-d3); Voriconazole-d3; UNII-7M7YKX2N15; (αR,βS)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol-d3; VFEND-d3 (labeled analog)
EINECS	Contact for details

Quality Control

Our Voriconazole-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is thoroughly characterized by NMR, MS, and HPLC to confirm identity, deuterium incorporation, and purity. We provide comprehensive Certificates of Analysis (COA) detailing assay, isotopic enrichment, and impurity profiles, supporting compliance with GMP/GLP guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium incorporation)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.