Description

Neuroserpin, Human Recombinant is a high-purity, biologically active serine protease inhibitor (serpin) protein expressed in a mammalian system. This recombinant form is critical for advanced neurological research and therapeutic development due to its specific role in protecting neurons from proteolytic damage. It is an essential reagent for researchers and developers in neuroscience, pharmaceutical R&D, and biotechnology focusing on conditions like stroke, epilepsy, and neurodegenerative diseases.

Application

• Biochemical Research: Used as a standard or active component in studies of serpin function, neuroprotection, and protease inhibition kinetics.
• Drug Discovery & Development: Serves as a key target or therapeutic candidate in preclinical research for neurological disorders.
• In Vitro Diagnostics (IVD): May be utilized in the development of enzyme-linked immunosorbent assays (ELISAs) or other diagnostic tests for biomarker detection.
• Cell Culture & Neuroscience Models: Applied in neuronal cell culture systems to study apoptosis, excitotoxicity, and cellular survival pathways.
• Protein-Protein Interaction Studies: Essential for investigating binding interactions with target proteases like tissue plasminogen activator (tPA).
• Reference Standard: Acts as a purity and activity reference standard for quality control in related biopharmaceutical production.

Basic Information

Product Name	Neuroserpin, Human Recombinant
CAS No.	188364-82-1
Molecular Formula	Contact for details
Molecular Weight	~45-55 kDa (Glycosylated form)
Synonyms	SerpinI1 (Human Recombinant); PI12; Protease Inhibitor 12; Neuroserpin Precursor; Recombinant Human Neuroserpin; hNeuroserpin; SERPINI1 Protein
EINECS	Contact for details

Quality Control

Our Neuroserpin, Human Recombinant is produced under stringent conditions to ensure high biological activity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including SDS-PAGE, HPLC for purity, and functional activity assays (e.g., tPA inhibition). A comprehensive Certificate of Analysis (COA) detailing purity, concentration, endotoxin levels, and biological activity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is at room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE)	≥ 95%
Purity (HPLC)	≥ 98.0%
Identification (Mass Spec)	Conforms
Biological Activity	Contact for details
Endotoxin Level	< 1.0 EU/µg
Protein Content	Determined by UV absorbance
Solubility	Soluble in water or buffered saline

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.