Description

Gp100 (619-627) is a synthetic peptide fragment derived from the glycoprotein 100 melanoma antigen, with the CAS Registry Number 187987-68-4. This compound is a critical research tool for the development of targeted immunotherapies and diagnostic assays in oncology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cancer vaccine development and T-cell receptor analysis.

Application

• Immunotherapy Research: As a defined antigenic epitope for studying melanoma-specific T-cell responses and immune recognition.
• Cancer Vaccine Development: A key component in preclinical studies for peptide-based vaccine candidates targeting melanoma.
• Diagnostic Reagent: Used in the development and validation of ELISA, ELISPOT, or flow cytometry-based assays to detect antigen-specific immune cells.
• T-Cell Receptor (TCR) Analysis: Serves as a stimulating antigen for the isolation, expansion, and functional characterization of tumor-infiltrating lymphocytes (TILs).
• Biomarker Studies: Employed in research to understand antigen presentation and processing mechanisms in melanoma cells.
• Reference Standard: Acts as a high-purity standard for quality control in the production of related immunotherapeutic peptides.

Basic Information

Item	Detail
Product Name	Gp100 (619-627)
CAS No.	187987-68-4
Molecular Formula	C50H78N14O15
Molecular Weight	1083.2 g/mol
Synonyms	gp100(619-627); Melanoma Antigen gp100 Peptide (619-627); HLA-A*0201-restricted Melanoma Antigen Peptide; ITDQVPFSV; gp100619-627; Peptide ITDQVPFSV; gp100 Peptide Fragment; Antigenic Peptide ITDQVPFSV
EINECS	Contact for details

Quality Control

Our Gp100 (619-627) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided to ensure compliance with research-grade standards and support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. As a hygroscopic (moisture-sensitive) peptide, allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider lyophilized powder under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical
Solvent Residues	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.