Description

Endostatin is a potent, naturally occurring protein fragment known for its specific anti-angiogenic properties, inhibiting the formation of new blood vessels. This makes it a critical research compound for studying tumor growth, metastasis, and various angiogenesis-dependent diseases. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life science sectors for preclinical studies and therapeutic development.

Application

• Cancer Research: Fundamental tool for studying angiogenesis inhibition, tumor growth, and metastasis in various cancer models.
• Therapeutic Development: Serves as a reference standard and active ingredient in the R&D of novel anti-cancer biologics and drug delivery systems.
• Biochemical Assays: Used in cell-based assays, enzyme-linked immunosorbent assays (ELISAs), and other in vitro tests to evaluate angiogenic pathways.
• Ophthalmology Research: Investigation of ocular neovascular diseases such as age-related macular degeneration (AMD) and diabetic retinopathy.
• Inflammatory Disease Models: Research into conditions like rheumatoid arthritis, where pathological angiogenesis plays a role.
• Academic & Institutional Research: Used in universities and research institutes for fundamental studies in cell biology and vascular development.

Basic Information

Product Name	Endostatin
CAS No.	187888-07-9
Molecular Formula	C13H16N4O4S
Molecular Weight	324.36 g/mol
Synonyms	Endostatin (human); Angiogenesis inhibitor, human endostatin; Collagen XVIII fragment; NC1 domain of collagen α-1(XVIII) chain; Recombinant Human Endostatin; rh-Endostatin
EINECS	Contact for details

Quality Control

Our Endostatin is produced under stringent conditions to ensure high purity and consistent biological activity. Each batch is subjected to a comprehensive suite of analytical tests, including HPLC for purity, SDS-PAGE, mass spectrometry, and endotoxin level analysis. Certificates of Analysis (COA) detailing purity, potency (specific activity), and sterility (where applicable) are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. Aliquot upon receipt for single-use to maintain optimal activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Molecular Weight	~20 kDa (SDS-PAGE)
Biological Activity	Determined by endothelial cell proliferation assay
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.