Description

[Lys(Ac)11]-Charybdotoxin CAS NO 187887-48-5 is a chemically modified, acetylated derivative of the potent potassium channel blocker, charybdotoxin. This specific modification at the lysine-11 residue is critical for advanced biochemical and pharmacological research, particularly in studying ion channel structure-function relationships and ligand-receptor interactions. It is an essential tool compound for researchers and developers in neuroscience, cardiovascular research, and toxicology, enabling precise modulation and study of high-conductance calcium-activated potassium (BK) channels.

Application

• Ion Channel Research: A key pharmacological tool for blocking and studying large-conductance calcium-activated potassium (BK, Maxi-K) channels.
• Neuroscience Studies: Used to investigate the role of BK channels in neuronal excitability, neurotransmitter release, and synaptic plasticity.
• Cardiovascular Research: Applied in studies of vascular tone regulation and smooth muscle physiology where BK channels are involved.
• Toxicology & Venom Peptide Analysis: Serves as a reference standard for the study of scorpion venom peptides and their mechanisms of action.
• Drug Discovery Platforms: Utilized in high-throughput screening assays to identify novel modulators of potassium channels.
• Structural Biology: The acetylated derivative aids in crystallography and NMR studies to map toxin-channel interaction sites without affecting key functional residues.
• Bioconjugation & Probe Development: The modified lysine residue provides a handle for further chemical conjugation with fluorescent or affinity tags.

Basic Information

Product Name	[Lys(Ac)11]-Charybdotoxin
CAS No.	187887-48-5
Molecular Formula	C198H304N58O61S7
Molecular Weight	~4550.2 g/mol (monoisotopic)
Synonyms	Acetyl-Lys11-Charybdotoxin; Charybdotoxin, 11-(N6-acetyl-L-lysine)-; L-11-Acetylcharybdotoxin; Acetylated Charybdotoxin (Lys11); CTX, Ac-Lys11; Potassium channel blocker toxin analogue; ShK toxin analogue (scorpion); Leiurus quinquestriatus hebraeus venom peptide derivative
EINECS	Contact for details

Quality Control

Our [Lys(Ac)11]-Charybdotoxin is produced and analyzed under stringent conditions to ensure the highest standards of purity, identity, and biological activity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity by HPLC, molecular weight confirmation by mass spectrometry, and peptide content. We adhere to GMP-like guidelines for research-grade peptides, ensuring batch-to-batch consistency and reliability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under inert atmosphere or in a vacuum desiccator. Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by ESI-MS or MALDI-TOF
Purity (HPLC)	≥ 95% (at 214 nm)
Peptide Content	≥ 80% (by weight)
Single-Charged Mass	~4550.2 ± 2 Da
Water Content (KF)	≤ 5.0%
Acetic Acid Content (HPLC)	≤ 10% (by weight)
Biological Activity	Confirmed by functional assay (e.g., BK channel inhibition)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.