Description

1-Boc-Isonipecotic Acid Hydrazide is a high-purity, protected heterocyclic building block of significant importance in modern synthetic chemistry. Its core value lies in its bifunctional nature, featuring both a Boc-protected amine and a reactive hydrazide group, enabling its use as a versatile intermediate for the construction of complex molecular architectures. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, peptide mimetics, and the synthesis of novel heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing piperidine or hydrazine motifs.
• Peptide & Peptidomimetic Chemistry: Used to incorporate modified amino acid units or as a linker/spacer in peptide chain elongation and cyclization reactions.
• Heterocyclic Compound Synthesis: Serves as a precursor for the construction of various nitrogen-containing heterocycles, such as pyrazoles, triazoles, and fused ring systems.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides that utilize hydrazide or piperidine-based chemistries.
• Crosslinking Agent: Its reactive hydrazide group can be utilized in polymer chemistry and material science for crosslinking applications with carbonyl-containing polymers.
• Chemical Biology Probes: Useful for the synthesis of affinity probes, tags, and other tools for studying biological systems and target identification.

Basic Information

Product Name	1-Boc-Isonipecotic Acid Hydrazide
CAS No.	187834-88-4
Molecular Formula	C11H21N3O3
Molecular Weight	243.31 g/mol
Synonyms	1-Boc-4-piperidinecarboxylic acid hydrazide; 1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid hydrazide; tert-Butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate; 4-Hydrazinylcarbonyl-piperidine-1-carboxylic acid tert-butyl ester; N-Boc-isonipecotic acid hydrazide; Boc-Isonipecotic hydrazide; 1-Boc-piperidine-4-carbohydrazide
EINECS	Contact for details

Quality Control

Our 1-Boc-Isonipecotic Acid Hydrazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.