Description

(R)-1-[(S)-2-[Bis(4-Methoxy-3,5-Dimethylphenyl)Phosphino]Ferrocenyl}Ethyldi-Tert-Butylphosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in advanced asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, critical for producing single-isomer intermediates in pharmaceutical and fine chemical synthesis. This product is essential for R&D scientists and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control for manufacturing active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• As a key chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure amino acids, amines, and alcohols.
• Catalyst component in asymmetric C-C bond-forming reactions, such as cross-couplings and allylic substitutions.
• Critical for the scale-up production of chiral pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
• Use in academic and industrial R&D for developing novel catalytic methodologies.
• Enabling technology for the synthesis of flavors, fragrances, and agrochemicals with high optical purity.
• As a reference standard for analytical method development and quality control in chiral synthesis.

Basic Information

Item	Details
Product Name	(R)-1-[(S)-2-[Bis(4-Methoxy-3,5-Dimethylphenyl)Phosphino]Ferrocenyl}Ethyldi-Tert-Butylphosphine
CAS No.	187733-50-2
Molecular Formula	C43H55FeO2P2
Molecular Weight	712.68 g/mol
Synonyms	(R)-(S)-Josiphos SL-J009-1; (R)-1-[(S)-2-(Bis(4-methoxy-3,5-dimethylphenyl)phosphino)ferrocenyl]ethyldi-tert-butylphosphine; Josiphos ligand SL-J009-1; (R)-1-[(S)-2-[Di(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl]ethyldi(tert-butyl)phosphine; Ferrocenyl Josiphos ligand; Chiral Josiphos-type ligand; (R,S)-SL-J009-1; Asymmetric hydrogenation ligand J009
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management to ensure exceptional purity and enantiomeric excess (ee) for reliable catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as chemical purity (by HPLC/NMR), chiral purity, and metal content. Our production adheres to cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxygen and moisture, containers should be flushed with inert gas before resealing after each use.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (ee)	≥ 99.0%
Solubility Test	Soluble in common organic solvents (e.g., Toluene, DCM, THF)
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.