Description

Interleukin-12 is a pivotal heterodimeric cytokine that plays a critical role in bridging innate and adaptive immunity. Its primary function is to stimulate the production of interferon-gamma (IFN-γ) from T cells and natural killer (NK) cells, making it a key regulator of cell-mediated immune responses. This protein is essential for researchers and developers in the fields of immunology, oncology, and biopharmaceuticals, particularly for studying Th1 cell differentiation, anti-tumor immunity, and as a potential therapeutic agent or vaccine adjuvant.

Application

• Immunological Research: Fundamental studies on T-cell and NK cell activation, Th1/Th2 balance, and cell-mediated immune response pathways.
• Oncology and Cancer Research: Investigation of anti-tumor mechanisms and evaluation as an immunotherapeutic agent to enhance anti-cancer immune responses.
• Infectious Disease Studies: Research into host defense against intracellular pathogens, including viruses, bacteria, and parasites.
• Vaccine Adjuvant Development: Exploration of its potential to enhance the efficacy of vaccines by promoting a robust Th1-type immune response.
• Biopharmaceutical Production: Used as a critical raw material or reference standard in the development and quality control of biologic drugs.
• Autoimmune Disease Models: Research tool for understanding and modeling diseases driven by excessive Th1 responses.

Basic Information

Product Name	Interleukin-12
CAS No.	187348-17-0
Molecular Formula	C690H1086N186O204S10
Molecular Weight	~15.5 kDa (Heterodimer, p35 subunit: ~35 kDa, p40 subunit: ~40 kDa)
Synonyms	IL-12; IL12; Interleukin 12; Cytotoxic Lymphocyte Maturation Factor; CLMF; NK Cell Stimulatory Factor; NKSF; p70; IL-12 p70; Natural Killer Cell Stimulatory Factor; T-Cell Stimulating Factor
EINECS	Contact for details

Quality Control

Our Interleukin-12 is produced and tested under stringent conditions to ensure the highest standards of purity and biological activity, suitable for critical research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, endotoxin levels, sterility, and biological potency assays. We adhere to relevant quality guidelines to support our global clientele in pharmaceutical, academic, and biotechnology sectors.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to prevent repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under controlled, dry conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Corresponds to standard
Purity (HPLC)	≥ 95%
Biological Activity (Cell-based assay)	≥ 1 x 106 units/mg
Endotoxin Level (LAL)	< 1.0 EU/μg
Sterility (Membrane Filtration)	Sterile
Protein Content (UV Spectroscopy)	Contact for details
Solubility	Soluble in sterile PBS or cell culture medium

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.