Description

(Xyl)2P(O)H CAS NO 187344-92-9 is a specialized organophosphorus compound, specifically a secondary phosphine oxide, known for its utility as a versatile ligand and reagent in advanced chemical synthesis. Its significance lies in its ability to facilitate key catalytic transformations and serve as a crucial building block for complex molecular architectures. This high-value intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors who require precise and reliable synthetic tools.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring phosphine oxide motifs for biological activity or as synthetic handles.
• Catalysis & Ligand Synthesis: Serves as a valuable precursor for generating novel phosphine ligands used in transition metal catalysis, including cross-coupling and hydrogenation reactions.
• Agrochemical Research: Employed in the development of new herbicides, insecticides, and plant growth regulators where the phosphine oxide functional group imparts desired properties.
• Polymer & Material Science: Used as a monomer or additive in the production of specialty polymers, flame retardants, and advanced materials with tailored thermal or mechanical characteristics.
• Organic Synthesis Reagent: Functions as a nucleophile or a stabilizing agent in various organic transformations, including the synthesis of complex natural products and fine chemicals.
• Coordination Chemistry: Acts as a ligand for metal complexes in research focused on catalysis, material properties, and molecular recognition.

Basic Information

Product Name	(Xyl)2P(O)H
CAS No.	187344-92-9
Molecular Formula	C16H19OP
Molecular Weight	258.30 g/mol
Synonyms	Bis(2,4,6-trimethylphenyl)phosphine oxide; Di(2,4,6-trimethylphenyl)phosphine oxide; Di(mesityl)phosphine oxide; (Mes)2P(O)H; Dimesitylphosphine oxide; 2,4,6-Trimethylphenylphosphine oxide, bis-; Phosphine oxide, bis(2,4,6-trimethylphenyl)-
EINECS	Contact for details

Quality Control

Our production of (Xyl)2P(O)H adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR (¹H, ³¹P), and GC analysis, to verify identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider maintaining the material under an inert atmosphere (e.g., nitrogen or argon) to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.