Description

1,4,7,10-Tetraazacyclododecane-1,7-Diacetic Acid, Hydrochloride is a high-purity, functionalized macrocyclic chelating agent, specifically a derivative of cyclen (1,4,7,10-tetraazacyclododecane). This compound is a critical intermediate for synthesizing advanced bifunctional chelators used in diagnostic and therapeutic radiopharmaceuticals. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and medical imaging sectors who require precise and reliable building blocks for targeted molecular imaging agents.

Application

• Bifunctional Chelator Synthesis: Primary building block for creating ligands that bind both radioactive metals (e.g., 68Ga, 177Lu, 64Cu) and targeting biomolecules (antibodies, peptides).
• Radiopharmaceutical Development: Key precursor for developing Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) imaging probes.
• Therapeutic Radiopharmaceuticals: Used in the synthesis of agents for targeted radionuclide therapy (TRT) in oncology.
• Contrast Agent Research: Intermediate for developing next-generation magnetic resonance imaging (MRI) contrast agents based on gadolinium or other lanthanides.
• Coordination Chemistry Studies: Valuable ligand for academic and industrial research into metal complexation kinetics, stability, and thermodynamics.
• Diagnostic Kit Formulation: Used in the production of cold kits for the convenient, on-site preparation of radiometal-labeled diagnostics.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1,7-Diacetic Acid, Hydrochloride
CAS No.	187240-51-3
Molecular Formula	C14H28N4O4 • xHCl
Molecular Weight	316.40 g/mol (free base)
Synonyms	DO2A; 1,7-DO2A; 1,4,7,10-Tetraazacyclododecane-1,7-diacetic acid hydrochloride; 1,7-Bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane hydrochloride; 1,7-DO2A•HCl; Cyclen-1,7-diacetic acid hydrochloride; 1,4,7,10-Tetraazacyclododecane-1,7-diacetate hydrochloride; DO2A ligand hydrochloride
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetraazacyclododecane-1,7-Diacetic Acid, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.