Description

5-Desethyl 5-Carboxy Pioglitazone is a key pharmaceutical intermediate and metabolite of the antidiabetic drug Pioglitazone. This compound is of significant importance for analytical and research purposes, particularly in pharmacokinetic studies, bioequivalence testing, and the development of new therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of reference standards and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of Pioglitazone and its metabolites in biological matrices.
• Metabolite Research: Critical for studying the metabolic pathway, pharmacokinetics, and pharmacodynamics of Pioglitazone in preclinical and clinical research.
• Impurity Profiling: Serves as a specified impurity standard in the quality control of Pioglitazone API, ensuring compliance with ICH guidelines.
• Bioanalytical Method Development: Employed in the development and validation of HPLC, LC-MS, and other analytical methods for drug monitoring.
• Drug Discovery & Development: Used as a building block or intermediate in the synthesis of novel thiazolidinedione derivatives for diabetes research.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., FDA, EMA) requiring characterization of drug metabolites.

Basic Information

Product Name	5-Desethyl 5-Carboxy Pioglitazone
CAS No.	186751-40-6
Molecular Formula	C18H19N2O3S
Molecular Weight	343.42 g/mol
Synonyms	5-Desethyl-5-carboxy Pioglitazone; M-IV Metabolite of Pioglitazone; 5-Carboxy Pioglitazone Derivative; 5-{4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyl}-2,4-thiazolidinedione-5-carboxylic Acid; 5-Carboxy-5-desethyl Pioglitazone; AD-4833 Metabolite; Pioglitazone Carboxylic Acid Metabolite
EINECS	Contact for details

Quality Control

Our 5-Desethyl 5-Carboxy Pioglitazone is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.