Description

1-(4-Chloro-2-Fluorophenyl)Propan-1-One is a high-purity organic building block and key pharmaceutical intermediate. This compound is valued for its precise molecular structure, which is critical for synthesizing more complex active pharmaceutical ingredients (APIs) and advanced materials. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds and optimizing synthetic routes.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory research.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and pesticides, leveraging the halogenated phenyl group for bioactivity.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials due to its aromatic and ketone functionality.
• Chemical Reference Standard: Employed as an analytical standard in quality control (QC) and research laboratories for method development and validation.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, carbonyl chemistry, and fluorination studies to create diverse chemical libraries for screening.

Basic Information

Product Name	1-(4-Chloro-2-Fluorophenyl)Propan-1-One
CAS No.	186685-49-4
Molecular Formula	C9H8ClFO
Molecular Weight	186.61 g/mol
Synonyms	Propiophenone, 4'-chloro-2'-fluoro-; 4-Chloro-2-fluoropropiophenone; 1-Propanone, 1-(4-chloro-2-fluorophenyl)-; 2-Fluoro-4-chloropropiophenone; 4'-Chloro-2'-fluoropropiophenone; p-Chloro-o-fluoropropiophenone; 186685-49-4
EINECS	Contact for details

Quality Control

Our 1-(4-Chloro-2-Fluorophenyl)Propan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.