Description

n-Boc-2-Aminophenol is a protected aniline derivative where the amine group is shielded by a tert-butoxycarbonyl (Boc) group, making it a crucial building block in synthetic organic chemistry. This compound matters because it provides a stable, orthogonal protecting group strategy, enabling selective reactions on the phenol moiety during complex multi-step syntheses. It is primarily needed by pharmaceutical and agrochemical R&D laboratories for the synthesis of active pharmaceutical ingredients (APIs), heterocyclic compounds, and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, particularly those containing benzoxazole or benzimidazole cores.
• Peptide Chemistry: Used in the preparation of tyrosine derivatives with protected amine functionalities for solid-phase peptide synthesis (SPPS).
• Agrochemical Synthesis: Intermediate in the production of herbicides, fungicides, and other crop protection agents.
• Material Science: Monomer or precursor for the synthesis of specialty polymers, dyes, and photoactive materials.
• Chemical Biology: Useful for creating probes and linkers where a protected, modifiable phenol group is required.
• Academic & Industrial Research: Serves as a versatile starting material for methodological development and the construction of chemical libraries.

Basic Information

Product Name	n-Boc-2-Aminophenol
CAS No.	186663-74-1
Molecular Formula	C₁₁H₁₅NO₃
Molecular Weight	209.24 g/mol
Synonyms	2-[(tert-Butoxycarbonyl)amino]phenol; 2-Aminophenol N-Boc derivative; tert-Butyl (2-hydroxyphenyl)carbamate; N-Boc-o-aminophenol; N-(tert-Butoxycarbonyl)-2-aminophenol; Boc-2-AP; Boc-protected 2-aminophenol; 2-Hydroxyaniline N-Boc protected
EINECS	Contact for details

Quality Control

Our n-Boc-2-Aminophenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other relevant methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be handled and stored away from strong light sources. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.