Description

4-(2-Oxo-Piperidin-1-Yl)-Benzonitrile CAS NO 186651-05-8 is a high-purity pharmaceutical intermediate featuring a benzonitrile core linked to a 2-oxopiperidine moiety. This compound is valued for its role as a critical building block in the synthesis of complex bioactive molecules, particularly in central nervous system (CNS) and oncology research. It is primarily sought by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting neurological disorders and cancer.
• Chemical Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization due to its versatile reactive sites.
• Research & Development (R&D): Essential for academic and industrial research labs focusing on heterocyclic chemistry and piperidine-based compound libraries.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the multi-step synthesis of potential APIs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP guidelines.

Basic Information

Item	Details
Product Name	4-(2-Oxo-Piperidin-1-Yl)-Benzonitrile
CAS No.	186651-05-8
Molecular Formula	C₁₂H₁₂N₂O
Molecular Weight	200.24 g/mol
Synonyms	4-(2-Oxo-1-piperidinyl)benzonitrile; 1-(4-Cyanophenyl)-2-piperidinone; 4-(2-Oxopiperidin-1-yl)benzonitrile; 4-(2-Oxo-1-piperidyl)benzonitrile; 1-(4-Cyanophenyl)piperidin-2-one; 4-(2-Oxopiperidino)benzonitrile; 186651-05-8
EINECS	Contact for details

Quality Control

Our 4-(2-Oxo-Piperidin-1-Yl)-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.