Description

n-(4-Aminophenyl)-4-Fluorobenzamide is a high-purity, specialized organic intermediate featuring both an aromatic amine and a fluorinated benzamide moiety. This unique bifunctional structure makes it a valuable building block for the synthesis of complex molecules in advanced research and development. It is primarily utilized by pharmaceutical, agrochemical, and advanced material scientists seeking to incorporate fluorinated aromatic systems into novel compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the research and synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases where fluorination can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and insecticides, leveraging the fluorine atom to improve pesticidal activity and environmental persistence.
• Liquid Crystal & OLED Material Research: Used in the development of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs) due to its potential influence on molecular polarity and packing.
• Polymer Modification: Acts as a monomer or cross-linking agent in the creation of specialty polymers, such as polyimides or epoxy resins, to impart specific thermal or chemical resistance properties.
• Bioconjugation & Probe Development: The reactive amine group allows for conjugation to biomolecules, making it useful in creating fluorescent probes, diagnostic agents, or targeted drug delivery systems for life science research.
• Academic & Contract Research: Essential reagent for methodological studies in organic synthesis, particularly in palladium-catalyzed cross-coupling reactions and amide bond formation strategies.

Basic Information

Product Name	n-(4-Aminophenyl)-4-Fluorobenzamide
CAS No.	186544-90-1
Molecular Formula	C13H11FN2O
Molecular Weight	230.24 g/mol
Synonyms	4'-Amino-4-fluorobenzanilide; N-(4-Aminophenyl)-4-fluorobenzamide; 4-Fluoro-N-(4-aminophenyl)benzamide; p-Fluorobenzoic acid (4-aminophenyl)amide; 1-Amino-4-[(4-fluorobenzoyl)amino]benzene; Benzanilide, 4'-amino-4-fluoro-; 4-Fluorobenzoic acid 4-aminophenylamide
EINECS	Contact for details

Quality Control

Every batch of n-(4-Aminophenyl)-4-Fluorobenzamide is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications and results from advanced techniques like HPLC, GC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent oxidation and moisture uptake. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.