Description

1,3-Dioxolane, 4-Ethynyl-2,2-Dimethyl-, (R)- (9Ci) is a high-purity, chiral building block of significant interest in advanced organic synthesis. Its unique structure, featuring a protected aldehyde equivalent and a terminal alkyne group, makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting new therapeutic entities.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where its stereochemistry can be critical for biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chiral ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of advanced polymers and functional materials that require specific, rigid molecular backbones.
• Academic & Industrial R&D: A valuable tool for methodology development in organic chemistry, enabling new C-C bond forming reactions and cyclization strategies.

Basic Information

Product Name	1,3-Dioxolane, 4-Ethynyl-2,2-Dimethyl-, (R)- (9Ci)
CAS No.	186521-82-4
Molecular Formula	C7H10O2
Molecular Weight	126.15 g/mol
Synonyms	(R)-4-Ethynyl-2,2-dimethyl-1,3-dioxolane; (4R)-4-Ethynyl-2,2-dimethyl-1,3-dioxolane; (R)-2,2-Dimethyl-4-ethynyl-1,3-dioxolane; 4-Ethynyl-2,2-dimethyl-1,3-dioxolane, (R)-; D-Glyceraldehyde Acetonide, Propargylated; (R)-(-)-2,2-Dimethyl-4-ethynyl-1,3-dioxolane; Propargyl Acetal of (R)-Glyceraldehyde
EINECS	Contact for details

Quality Control

Our production of 1,3-Dioxolane, 4-Ethynyl-2,2-Dimethyl-, (R)- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical identity, and impurity profiles. We maintain traceability and documentation in line with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and potential concentration changes. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.