Description

Phenylalanine, n-[(1,1-Dimethylethoxy)Carbonyl]-2-Fluoro- is a protected, fluorinated derivative of the essential amino acid L-phenylalanine, serving as a critical building block in advanced organic synthesis. This compound matters for its role in introducing fluorine atoms and chiral phenylalanine moieties into complex molecules, enabling the fine-tuning of biological activity and physicochemical properties. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel peptides, protease inhibitors, and other bioactive compounds where enhanced metabolic stability and binding affinity are required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated peptide-based drugs, including protease inhibitors and hormone analogs.
• Agrochemical Research: Used in developing novel, fluorinated active ingredients with improved pest selectivity and environmental stability.
• Peptide Chemistry: Essential for solid-phase and solution-phase peptide synthesis (SPPS) to incorporate fluorinated phenylalanine residues.
• Proteomics & Biochemistry: Serves as a tool compound for studying enzyme mechanisms and protein-protein interactions using fluorine as a probe.
• Material Science: Potential monomer for creating specialized polymers and coatings with unique surface properties.
• Academic & Contract Research: Used in university and CRO laboratories for medicinal chemistry programs and method development.

Basic Information

Item	Details
Product Name	Phenylalanine, n-[(1,1-Dimethylethoxy)Carbonyl]-2-Fluoro-
CAS No.	186431-96-9
Molecular Formula	C₁₄H₁₈FNO₄
Molecular Weight	283.30 g/mol
Synonyms	Boc-2-Fluoro-DL-phenylalanine; N-Boc-2-fluoro-DL-phenylalanine; 2-Fluoro-N-[(tert-butoxy)carbonyl]phenylalanine; tert-Butyl (2-fluorophenyl)alaninate; N-(tert-Butoxycarbonyl)-2-fluorophenylalanine; Boc-Phe(2-F)-OH; (RS)-2-[(tert-Butoxycarbonyl)amino]-3-(2-fluorophenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our Phenylalanine, n-[(1,1-Dimethylethoxy)Carbonyl]-2-Fluoro- is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and NMR for structural confirmation, to ensure it meets the exacting standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.