Description

Amyloid β-Protein (1-37) CAS NO 186359-67-1 is a synthetic peptide fragment corresponding to the first 37 amino acids of the human amyloid-beta protein. This specific sequence is a critical research tool for studying the mechanisms of amyloid aggregation, a key pathological hallmark in Alzheimer's disease and other neurodegenerative conditions. It is essential for scientists and pharmaceutical developers in neuroscience research, drug discovery, and diagnostic assay development, providing a defined substrate for investigating protein misfolding and toxicity.

Application

• Neuroscience Research: Fundamental studies on the aggregation kinetics, structure, and neurotoxicity of amyloid-beta peptides.
• Drug Discovery Screening: Used as a target substrate in high-throughput assays to identify and validate potential therapeutic inhibitors of amyloid aggregation.
• Biomarker & Diagnostic Development: Serves as a reference standard or antigen in the development of immunoassays (ELISA, Western Blot) for detecting amyloid-beta variants.
• Biophysical Studies: Utilized in techniques like NMR, CD spectroscopy, and electron microscopy to elucidate the secondary and tertiary structure of amyloid peptides.
• Cell Culture & Animal Model Studies: Applied in vitro and in vivo to model amyloid-induced cytotoxicity and pathological effects relevant to Alzheimer's disease.

Basic Information

Product Name	Amyloid β-Protein (1-37)
CAS No.	186359-67-1
Molecular Formula	C185H277N51O57S
Molecular Weight	4074.6 g/mol
Synonyms	Amyloid β-Protein (1-37); Aβ(1-37); Amyloid β-Peptide (1-37); β-Amyloid (1-37); Amyloid Beta (1-37) Fragment; DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; Aβ1-37; Amyloid-β Protein Fragment 1-37
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (1-37) is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Quality is verified through a comprehensive suite of analytical techniques, including reverse-phase HPLC for purity assessment and mass spectrometry (MS) for identity confirmation. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Solubility	Soluble in water or dilute acetic acid
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.