Description

Montelukast 1,2-Diol_X000B_(Mixture Of Diastereomers) is a key chiral intermediate in the synthesis of the leukotriene receptor antagonist Montelukast Sodium. This compound matters for its critical role in ensuring the stereochemical integrity and efficacy of the final active pharmaceutical ingredient (API). Pharmaceutical manufacturers and advanced fine chemical suppliers require this high-purity intermediate for the reliable and scalable production of asthma and allergy medications.

Application

• Primary Intermediate in the synthesis of Montelukast Sodium API.
• Pharmaceutical Research & Development (R&D) for process optimization and new route development.
• Generic Drug Manufacturing for the production of leukotriene receptor antagonist therapies.
• Contract Manufacturing Organizations (CMOs) supplying critical building blocks for complex API synthesis.
• Reference Standard for analytical method development and quality control in API production.

Basic Information

Product Name	Montelukast 1,2-Diol_X000B_(Mixture Of Diastereomers)
CAS No.	186352-97-6
Molecular Formula	C35H36ClNO3S
Molecular Weight	586.18 g/mol
Synonyms	1-(((1-(R)-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid 1,2-diol; Montelukast Diol Intermediate; (1R)-1-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][3-[2-(1-Hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic Acid 1,2-Diol; Montelukast Diol Diastereomer Mixture; SQ 31,636 Diol; MK-0476 Diol Intermediate
EINECS	Contact for details

Quality Control

Our Montelukast 1,2-Diol intermediate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for diastereomeric ratio and purity, to ensure it meets the stringent requirements for pharmaceutical synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in the original sealed container to prevent degradation. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Diastereomeric Ratio (HPLC)	Specified per grade
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.