Description

A-(Fmoc-Amino)-Cyclohexaneacetic Acid is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled incorporation of a cyclohexylacetic acid side chain while protecting the amine functionality with the acid-labile Fmoc group. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the automated synthesis of complex peptides.
• Pharmaceutical Research: Used in the discovery and development of peptide drugs targeting GPCRs and other biological pathways.
• Bioconjugation: Serves as a linker or spacer molecule for attaching peptides to surfaces, carriers, or other biomolecules.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify bioactive compounds.
• Chemical Biology Probes: Integral for synthesizing labeled or modified peptides used in mechanistic studies and imaging.
• API Intermediate: Potential use as a sophisticated intermediate in the synthesis of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	A-(Fmoc-Amino)-Cyclohexaneacetic Acid
CAS No.	186320-22-9
Molecular Formula	C23H25NO4
Molecular Weight	379.45 g/mol
Synonyms	(1R,2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]cyclohexaneacetic Acid; Fmoc-(1R,2R)-2-Aminocyclohexylacetic Acid; trans-Fmoc-2-Aminocyclohexaneacetic Acid; Fmoc-Ach-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-aminocyclohexaneacetic Acid; (1R,2R)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclohexane-1-acetic Acid; Fmoc-ACHA; Fmoc-trans-2-Aminocyclohexanecarboxylic Acid derivative
EINECS	Contact for details

Quality Control

Our A-(Fmoc-Amino)-Cyclohexaneacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.