Description

β-Amyloid (1-17) is a synthetic peptide fragment corresponding to the N-terminal region of the human amyloid-beta protein. This high-purity peptide is a critical research tool for studying the molecular mechanisms of Alzheimer's disease and related neurodegenerative conditions. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers for use in immunoassays, antibody production, and structure-activity relationship studies.

Application

• Biomedical Research: A key antigen for studying amyloid-beta aggregation, toxicity, and clearance pathways in Alzheimer's disease models.
• Antibody Development & Validation: Used as an immunogen for generating and characterizing sequence-specific monoclonal and polyclonal antibodies.
• Diagnostic Assay Development: Serves as a critical standard and coating antigen in ELISA, Western blot, and other immunoassays to detect amyloid-beta or related antibodies.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) platforms to identify compounds that inhibit amyloid-beta aggregation or interaction.
• Structural Biology Studies: Used in NMR, X-ray crystallography, and other biophysical techniques to elucidate the structure and dynamics of amyloid-beta fragments.
• Quality Control Reference: Acts as a certified reference material (CRM) for qualifying reagents and ensuring consistency in bioanalytical workflows.

Basic Information

Product Name	β-Amyloid (1-17)
CAS No.	186319-72-2
Molecular Formula	C84H131N25O26S
Molecular Weight	1955.2 g/mol
Synonyms	Amyloid β-Protein (1-17); Aβ (1-17); β-Amyloid (1-17); Amyloid β-Peptide (1-17); DAEFRHDSGYEVHHQKLV (Single-Letter Amino Acid Sequence); H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-OH
EINECS	Contact for details

Quality Control

Our β-Amyloid (1-17) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and mass confirmation by MS. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Molecular Weight	1955.2 ± 2.0 Da (by MS)
Solubility	Soluble in water or dilute acetic acid
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.