Description

(R)-(+)-p-Chloro-n-Acetyl-1-Methylbenzylamine is a high-purity chiral intermediate of significant importance in asymmetric synthesis. Its value lies in its role as a key building block for the production of enantiomerically pure pharmaceuticals and agrochemicals. This compound is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and fine chemical industries who require a reliable source of a specific stereoisomer to ensure the efficacy and safety of their final products.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and other therapeutic areas requiring high stereochemical purity.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and pesticides, where the specific (R)-enantiomer can provide enhanced biological activity and environmental safety.
• Catalyst Ligand Precursor: Serves as a starting material for the synthesis of novel chiral ligands used in asymmetric catalysis, enabling more efficient and selective chemical transformations.
• Fine Chemical Research: Employed in academic and industrial R&D laboratories for exploring new synthetic methodologies and developing novel chiral compounds with potential biological activity.
• Custom Synthesis: A foundational substrate for contract research and manufacturing organizations (CROs/CMOs) producing bespoke chiral molecules for client projects.

Basic Information

Product Name	(R)-(+)-p-Chloro-n-Acetyl-1-Methylbenzylamine
CAS No.	186296-21-9
Molecular Formula	C10H12ClNO
Molecular Weight	197.66 g/mol
Synonyms	(R)-1-(4-Chlorophenyl)-N-acetylethylamine; (R)-N-(1-(4-Chlorophenyl)ethyl)acetamide; (R)-α-Methyl-4-chlorobenzylacetamide; (R)-(+)-1-(4'-Chlorophenyl)ethylacetamide; (R)-N-Acetyl-1-(4-chlorophenyl)ethylamine; (R)-p-Chloro-α-methylbenzylacetamide; (R)-Acetamide, N-[1-(4-chlorophenyl)ethyl]-
EINECS	Contact for details

Quality Control

Our (R)-(+)-p-Chloro-n-Acetyl-1-Methylbenzylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for advanced synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, and chiral purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (ee, HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.