Description

(Asn670,Leu671)-Amyloid Beta/A4 Protein Precursor770 (667-676) CAS NO 186142-28-9 is a synthetic peptide fragment corresponding to a specific sequence of the amyloid precursor protein (APP). This high-purity research-grade peptide is a critical tool for investigating the molecular mechanisms underlying Alzheimer's disease and related amyloidogenic processes. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on neurodegenerative disorders and protein aggregation studies.

Application

• Biomedical Research: Used as a key antigen or reference standard in studies of amyloid-beta peptide formation, processing, and aggregation kinetics.
• Antibody Development & Validation: Serves as an immunogen or binding target for the production and characterization of antibodies specific to APP regions.
• Diagnostic Assay Development: Employed in the calibration and quality control of ELISA, Western blot, and other immunoassays targeting APP or its fragments.
• Enzyme Activity Studies: Acts as a substrate to study the activity of secretase enzymes (like BACE1) involved in APP cleavage.
• Structure-Activity Relationship (SAR) Studies: Provides a defined peptide sequence for investigating how specific amino acid modifications affect protein function and pathology.
• Cell Culture & In Vitro Models: Used to treat neuronal cell cultures to model amyloid-related toxicity and cellular responses.

Basic Information

Product Name	(Asn670,Leu671)-Amyloid Beta/A4 Protein Precursor770 (667-676)
CAS No.	186142-28-9
Molecular Formula	C48H78N14O16
Molecular Weight	1083.2 g/mol
Synonyms	APP (667-676) peptide; Amyloid Beta A4 Protein Precursor (667-676); APP770 (667-676); [Asn670, Leu671]-APP (667-676); AβPP (667-676); Amyloid Precursor Protein fragment 667-676; KEVMEDHVLK (single letter code); (Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-676)
EINECS	Contact for details

Quality Control

Every batch of our research peptides is produced under strict quality management and undergoes comprehensive analytical characterization. Standard quality control includes HPLC for purity verification and mass spectrometry (MS) for identity confirmation. We provide full traceability and Certificates of Analysis (COA) detailing purity, molecular weight, and analytical data, ensuring reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.