Description

(R)-(+)-5,5'-Dichloro-6,6'-Dimethoxy-2,2'-Bis(Diphenylphosphino)-1,1'-Biphenyl is a high-value, chiral bidentate phosphine ligand essential for asymmetric catalysis. This compound matters because it enables the precise control of stereochemistry in critical synthetic transformations, directly impacting the yield and purity of advanced pharmaceutical intermediates. Industrial chemists and R&D teams in the fine chemical and pharmaceutical sectors need it to develop enantiomerically pure active pharmaceutical ingredients (APIs) and other complex organic molecules.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Cross-Coupling Reactions: Facilitates asymmetric versions of Suzuki, Heck, and other C-C bond-forming reactions with high stereoselectivity.
• Pharmaceutical Intermediate Manufacturing: Critical for the production of chiral drugs in therapeutic areas such as oncology, cardiology, and central nervous system disorders.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new asymmetric catalytic processes.
• Catalyst Screening Libraries: Serves as a premium component in high-throughput screening kits for identifying optimal catalytic conditions.

Basic Information

Product Name	(R)-(+)-5,5'-Dichloro-6,6'-Dimethoxy-2,2'-Bis(Diphenylphosphino)-1,1'-Biphenyl
CAS No.	185913-98-8
Molecular Formula	C44H36Cl2O2P2
Molecular Weight	721.60 g/mol
Synonyms	(R)-(+)-5,5'-Dichloro-6,6'-dimethoxy-2,2'-bis(diphenylphosphino)-1,1'-biphenyl; (R)-Cl-MeO-BIPHEP; (R)-5,5'-Dichloro-6,6'-dimethoxy-2,2'-bis(diphenylphosphino)-1,1'-biphenyl; (R)-Cl-MeO-Biphep; (R)-BIPHEP(5,5'-Cl2,6,6'-(OMe)2); (R)-2,2'-Bis(diphenylphosphino)-5,5'-dichloro-6,6'-dimethoxy-1,1'-biphenyl; Ligand (R)-Cl-MeO-BIPHEP
EINECS	Contact for details

Quality Control

Every batch of (R)-(+)-5,5'-Dichloro-6,6'-Dimethoxy-2,2'-Bis(Diphenylphosphino)-1,1'-Biphenyl is manufactured under strict quality management systems. We guarantee high chemical purity and enantiomeric excess (ee) to meet the rigorous demands of catalytic applications. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles are provided with each shipment to ensure full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. Keep the container in a cool, dry, and well-ventilated area separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.