Description

(R)-(+)-5,5'-Dichloro-6,6'-Dimethoxy-2,2'-Bis(Diphenylphosphino)-1,1'-Biphenyl CAS NO 185913-97-7 is a high-value, chiral bisphosphine ligand, specifically the (R)-enantiomer of the Cl-MeO-BIPHEP family, which is essential for inducing stereoselectivity in asymmetric catalytic reactions. Its core value lies in enabling the production of enantiomerically pure intermediates and active pharmaceutical ingredients (APIs) with high efficiency and selectivity. This product is critically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for developing and scaling up advanced synthetic routes.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines, crucial for synthesizing chiral alcohols, amines, and acids.
• Pharmaceutical Intermediate Synthesis: Used in the catalytic production of key chiral building blocks for APIs in cardiovascular, central nervous system, and antiviral drug classes.
• Agrochemical Active Ingredient Manufacturing: Facilitates the asymmetric synthesis of herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Fine Chemical and Flavor/Fragrance Production: Enables the creation of high-value enantiopure compounds for specialty chemicals, flavors, and fragrances.
• Cross-Coupling Reactions: Can serve as a supporting ligand in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura couplings, to form biaryl structures.
• Academic and Industrial R&D: A vital tool for methodology development in academic laboratories and for process optimization in industrial research settings.

Basic Information

Item	Details
Product Name	(R)-(+)-5,5'-Dichloro-6,6'-Dimethoxy-2,2'-Bis(Diphenylphosphino)-1,1'-Biphenyl
CAS No.	185913-97-7
Molecular Formula	C44H34Cl2O2P2
Molecular Weight	731.57 g/mol
Synonyms	(R)-(+)-Cl-MeO-BIPHEP; (R)-5,5'-Dichloro-6,6'-dimethoxy-2,2'-bis(diphenylphosphino)-1,1'-biphenyl; (R)-Cl-MeO-BIPHEP; (R)-2,2'-Bis(diphenylphosphino)-5,5'-dichloro-6,6'-dimethoxy-1,1'-biphenyl; (R)-(+)-2,2'-Bis(diphenylphosphino)-5,5'-dichloro-6,6'-dimethoxybiphenyl; (R)-(+)-Bis(diphenylphosphino)-5,5'-dichloro-6,6'-dimethoxybiphenyl; (R)-BIPHEP-Cl(OMe); LICHEM Ligand (R)-Cl-MeO-BIPHEP
EINECS	Contact for details

Quality Control

Our (R)-(+)-Cl-MeO-BIPHEP is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chiral purity. Each lot undergoes comprehensive analytical testing, including HPLC for chemical purity and chiral HPLC or polarimetry for enantiomeric excess (e.e.) verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. Allow the sealed container to reach room temperature before opening to minimize moisture ingress and oxidation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% e.e.
Melting Point	Contact for details
Specific Rotation [α]D20	Contact for details
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.