Description

(R)-Monophos CAS NO 185449-80-3 is a high-purity, chiral phosphine ligand widely used in asymmetric synthesis. Its value lies in its ability to induce high enantioselectivity in catalytic reactions, which is critical for producing single-isomer active pharmaceutical ingredients (APIs) and fine chemicals. This product is essential for research and development scientists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable and effective chiral auxiliaries.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediate synthesis.
• Catalyst component in enantioselective C-C and C-X bond-forming reactions.
• Key reagent in the development of novel synthetic routes for chiral drug candidates.
• Use in academic and industrial research for method development in asymmetric catalysis.
• Potential application in the synthesis of chiral agrochemicals and flavors/fragrances.
• As a building block or precursor for more complex, tailored phosphine ligand systems.

Basic Information

Product Name	(R)-Monophos
CAS No.	185449-80-3
Molecular Formula	C31H32P2
Molecular Weight	466.53 g/mol
Synonyms	(R)-(+)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl; (R)-(+)-BINAP; (R)-BINAP; (R)-(+)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl; (R)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl; (R)-(+)-1,1'-Binaphthalene-2,2'-diylbis(diphenylphosphine); (6R)-6-(Diphenylphosphanyl)-[1,1'-binaphthalene]-2-yl-diphenylphosphane
EINECS	Contact for details

Quality Control

Our (R)-Monophos is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for demanding catalytic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and key impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific research or cGMP requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is easily oxidized and moisture-sensitive; containers should be flushed with inert gas after each opening to maintain purity.

Specification

Item	Specification
Appearance	Off-white to beige crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.