Description

Bis-Propargyl-Peg6 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring terminal propargyl groups. This compound is essential for facilitating controlled, site-specific bioconjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. It is a critical reagent for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced materials science, enabling the creation of stable, well-defined molecular constructs.

Application

• Bioconjugation and ADC Development: Serves as a hydrophilic, flexible spacer for linking cytotoxic drugs to antibodies in Antibody-Drug Conjugate (ADC) payload synthesis.
• Peptide and Protein Modification: Used for PEGylation to enhance solubility, stability, and pharmacokinetic properties of therapeutic biomolecules.
• Polymer and Dendrimer Synthesis: Acts as a versatile building block in the stepwise construction of functionalized polymers and dendritic structures via click chemistry.
• Surface Functionalization: Enables the covalent attachment of biomolecules or probes to azide-modified surfaces (e.g., chips, nanoparticles, beads) for biosensing and diagnostic applications.
• Cross-linking Agent: Utilized to create three-dimensional networks or hydrogels with tailored properties for drug delivery and tissue engineering.
• Chemical Probe Synthesis: Facilitates the labeling of biomolecules with fluorescent dyes, biotin, or other reporter groups for imaging and detection studies.

Basic Information

Product Name	Bis-Propargyl-Peg6
CAS No.	185378-83-0
Molecular Formula	C₂₂H₃₈O₈
Molecular Weight	430.54 g/mol
Synonyms	1,11-Bis(prop-2-yn-1-yloxy)-3,6,9-trioxaundecane; Propargyl-PEG6-propargyl; α,ω-Bis-propargyl hexaethylene glycol; Bis-propargyl PEG6; PEG6-dipropargyl ether; 3,6,9,12,15,18-Hexaoxahenicos-20-yne-1,21-diyl bis(2-propynyl) ether; 1,1'-(Oxybis(ethane-2,1-diyl))bis(oxy)bis(ethane-2,1-diyl) bis(prop-2-yn-1-yl) ether
EINECS	Contact for details

Quality Control

Our Bis-Propargyl-Peg6 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive research and development applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.