Description

Etanercept CAS NO 185243-69-0 is a recombinant fusion protein that functions as a soluble tumor necrosis factor (TNF) inhibitor. This product is critical for the development of biologic therapies targeting autoimmune and inflammatory diseases. It is primarily required by pharmaceutical manufacturers and biotech research organizations engaged in the production and development of biosimilar or innovative biologic drugs.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of biologic drugs targeting TNF-mediated pathways.
• Key intermediate in the research and development of biosimilar versions of established TNF inhibitor therapies.
• Critical material for preclinical and clinical studies investigating treatments for rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
• Essential component in process development and scale-up activities within biopharmaceutical manufacturing.
• Reference standard for quality control and analytical method development in biologic drug production.
• Used in biochemical research to study TNF-alpha biology and its role in inflammatory disease mechanisms.

Basic Information

Product Name	Etanercept
CAS No.	185243-69-0
Molecular Formula	C2224H3475N621O698S36
Molecular Weight	Approx. 51,600 Da
Synonyms	TNFR:Fc; TNF Receptor-IgG Fc Fusion Protein; Recombinant Human TNF Receptor:Fc Fusion Protein; Enbrel (Brand Name); Etanercept Recombinant; TNFRSF1B-Fc; p75-Fc; TNRF-Fc; TNF-α Inhibitor Fusion Protein
EINECS	Contact for details

Quality Control

Our Etanercept is manufactured under strict quality systems. Each batch is subjected to a comprehensive battery of analytical tests including identity, purity, potency, and impurity profiling to ensure it meets stringent specifications for biologic APIs. Certificates of Analysis (COA) are provided, detailing compliance with relevant pharmacopeial guidelines and in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive) and should be handled under controlled humidity conditions to maintain stability and activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE/RP-HPLC)	≥ 98.0%
Assay (Bioassay)	90.0% - 110.0% of labeled potency
Protein Content	90.0% - 110.0% of theoretical
Endotoxin	< 1.0 EU/mg
Host Cell Proteins	< 100 ppm
DNA (Residual Host)	< 10 pg/mg
Sterility (where applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.