Description

Fmoc-4-Aminobenzoic Acid is a key protected amino acid derivative widely used in solid-phase peptide synthesis (SPPS). This compound is essential for introducing the 4-aminobenzoic acid moiety into peptide chains while providing orthogonal protection for the amine group, which is crucial for complex peptide assembly. It is primarily utilized by research institutions, pharmaceutical companies, and CROs/CMOs engaged in the development of peptide-based therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a critical building block for incorporating unnatural or modified amino acid residues into peptide sequences.
• Pharmaceutical Intermediates: In the research and development of novel peptide drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation and Linker Chemistry: For creating peptide-based conjugates, drug-linker systems, or surface functionalization in biotechnological applications.
• Combinatorial Chemistry Libraries: As a versatile monomer for generating diverse compound libraries for high-throughput screening.
• Material Science: For synthesizing specialized polymers or surface coatings with specific bioactive properties.
• Academic and Industrial Research: Serving as a fundamental reagent in organic synthesis and medicinal chemistry projects.

Basic Information

Product Name	Fmoc-4-Aminobenzoic Acid
CAS No.	185116-43-2
Molecular Formula	C22H17NO4
Molecular Weight	359.37 g/mol
Synonyms	Fmoc-PABA; N-(9-Fluorenylmethoxycarbonyl)-4-aminobenzoic Acid; 4-[(9H-Fluoren-9-ylmethoxy)carbonylamino]benzoic Acid; Fmoc-4-Abz-OH; N-Fmoc-4-aminobenzoic Acid; Fmoc-Aminobenzoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]anthranilic Acid (related); PABA-Fmoc
EINECS	Contact for details

Quality Control

Our Fmoc-4-Aminobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production standards. Custom purity grades and specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	~195-205°C (dec.)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.