Description

Carbamic Acid, [(1R)-1-Phenylethyl]-, 1,1-Dimethylethyl Ester is a chiral carbamate derivative of significant interest in advanced organic synthesis. This compound serves as a crucial chiral building block and protecting group intermediate for the preparation of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing active pharmaceutical ingredients (APIs) and other high-value chiral molecules.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key precursor for the development of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Synthesis Building Block: Used in stereoselective reactions to introduce the (R)-1-phenylethyl chiral center into complex molecular architectures.
• Amino-Protecting Group Reagent: Functions as a tert-butoxycarbonyl (Boc) protecting group derivative for amines in multi-step synthetic sequences, especially where chirality must be preserved.
• Agrochemical Research & Development: Employed in the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Catalyst and Ligand Preparation: Serves as a starting material for synthesizing chiral ligands used in asymmetric catalysis, such as for hydrogenation or cross-coupling reactions.
• Academic and Industrial R&D: A valuable compound for methodological studies in organic chemistry and process development within fine chemical manufacturing.

Basic Information

Product Name	Carbamic Acid, [(1R)-1-Phenylethyl]-, 1,1-Dimethylethyl Ester
CAS No.	184888-43-5
Molecular Formula	C13H19NO2
Molecular Weight	221.30 g/mol
Synonyms	(R)-1-Phenylethyl carbamic acid tert-butyl ester; tert-Butyl (R)-(1-phenylethyl)carbamate; (R)-N-(1-Phenylethyl)carbamic Acid tert-Butyl Ester; (R)-1-Phenylethyl tert-butylcarbamate; (R)-N-Boc-1-phenylethylamine; Boc-(R)-1-phenylethylamine; (R)-α-Methylbenzylcarbamic Acid tert-Butyl Ester; (R)-N-tert-Butoxycarbonyl-α-methylbenzylamine
EINECS	Contact for details

Quality Control

Our Carbamic Acid, [(1R)-1-Phenylethyl]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and enantiomeric excess (ee) suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed specifications for identity, purity, and chiral purity are provided with every shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and batch-to-batch consistency for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.