Description

4-Amino-1,1,1-trifluoro-3-buten-2-one is a versatile fluorinated building block of significant interest in advanced organic synthesis. Its unique structure, featuring both an amino group and a reactive trifluoromethylated enone moiety, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries. It serves as a key precursor for the synthesis of fluorinated heterocycles and active pharmaceutical ingredients (APIs) where the introduction of fluorine atoms can dramatically alter a molecule's metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel fluorinated drug candidates, particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Fluorinated Heterocycle Construction: Serves as a precursor for creating valuable fluorinated pyrazoles, isoxazoles, and other nitrogen-containing heterocyclic scaffolds.
• Material Science Research: Employed in the development of specialty polymers and advanced materials that require fluorinated components for specific thermal or chemical resistance.
• Chemical Biology Probes: Useful for synthesizing fluorinated analogs of natural products or biochemical probes to study enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A high-value intermediate for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	4-Amino-1,1,1-trifluoro-3-buten-2-one
CAS No.	184848-89-3
Molecular Formula	C₄H₄F₃NO
Molecular Weight	139.08 g/mol
Synonyms	4-Amino-1,1,1-trifluorobut-3-en-2-one; 4-Amino-1,1,1-trifluoro-3-buten-2-one; 1,1,1-Trifluoro-4-amino-3-buten-2-one; 4-Aminotrifluorobut-3-en-2-one; 3-Buten-2-one, 4-amino-1,1,1-trifluoro-; ATFB; 4-Amino-1,1,1-trifluorobut-2-en-1-one (tautomeric form)
EINECS	Contact for details

Quality Control

Our 4-Amino-1,1,1-trifluoro-3-buten-2-one is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay purity and impurity profiles. We are committed to consistent quality and supply reliability for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or when opening the container to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.