Description

Homeobox Protein Pitx2 CAS NO 184787-43-7 is a highly purified, recombinant protein that plays a critical role in developmental biology and genetic research. This protein is essential for studying left-right asymmetry, ocular development, and the molecular pathways involved in Axenfeld-Rieger syndrome. It is a vital reagent for researchers and pharmaceutical developers in the fields of molecular biology, genetic disease modeling, and therapeutic target validation.

Application

• Biomedical Research: Used as a key reagent in studies of embryonic development, cell fate determination, and tissue-specific gene expression.
• Disease Mechanism Studies: Critical for investigating the molecular basis of genetic disorders such as Axenfeld-Rieger syndrome and other conditions linked to PITX2 mutations.
• Drug Discovery & Target Validation: Serves as a target protein in high-throughput screening assays to identify potential therapeutic compounds that modulate its activity.
• Protein-Protein Interaction Analysis: Utilized in pull-down assays, co-immunoprecipitation (Co-IP), and yeast two-hybrid screens to map interaction networks.
• Antibody Production & Validation: Acts as a pure antigen for the generation and specificity testing of polyclonal and monoclonal antibodies.
• Functional Genomics: Employed in gain-of-function and loss-of-function experiments to elucidate the role of PITX2 in various cellular contexts.
• Diagnostic Development: Potential use as a standard or control in the development of diagnostic assays for related genetic conditions.

Basic Information

Product Name	Homeobox Protein Pitx2
CAS No.	184787-43-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PITX2; Paired-like homeodomain transcription factor 2; RIEG1; IHG2; Brx1; ARP1; All1; Recombinant Human PITX2; Homeobox protein PITX2; Pituitary homeobox 2; IDG2; Otlx2; Recombinant Pitx2 Protein
EINECS	Contact for details

Quality Control

Our Homeobox Protein Pitx2 is produced under stringent conditions and undergoes rigorous quality testing to ensure high purity, biological activity, and batch-to-batch consistency. Each lot is analyzed for identity, purity (via SDS-PAGE and HPLC), endotoxin levels, and functional activity in relevant bioassays. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. Aliquot as recommended upon receipt to maintain optimal activity.

Specification

Item	Specification
Appearance	Lyophilized powder or clear solution
Purity (SDS-PAGE)	> 95%
Identification (Mass Spec)	Conforms
Endotoxin Level	< 1.0 EU/µg
Biological Activity	Determined by functional assay (e.g., DNA-binding EMSA)
Protein Concentration	As per COA
Buffer Composition	Provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.