Description

(+)-o-Isopropylidene-2,3-Dihydroxy-1,4-Bis[Bis(4-Trifluoromethylphenyl)Phosphino]Butane is a high-value, chiral bisphosphine ligand essential for asymmetric catalysis. Its core value lies in enabling highly enantioselective transformations, critical for producing single-isomer intermediates in fine chemical and pharmaceutical synthesis. This product is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediate synthesis.
• Catalyst component for the enantioselective synthesis of amino acids, amines, and other bioactive molecules.
• Key reagent in the development of transition metal catalysts for C-C and C-X bond-forming reactions.
• Use in academic and industrial research to explore new asymmetric catalytic methodologies.
• Potential application in the synthesis of electronic materials and liquid crystals where chirality influences properties.

Basic Information

Product Name	(+)-o-Isopropylidene-2,3-Dihydroxy-1,4-Bis[Bis(4-Trifluoromethylphenyl)Phosphino]Butane
CAS No.	184095-64-5
Molecular Formula	C38H30F12O2P2
Molecular Weight	808.58 g/mol
Synonyms	(+)-DIPAMP-TetraCF3; (R,R)-1,2-Bis[(o-methoxyphenyl)(phenyl)phosphino]ethane Tetra-CF3 Analog; (2R,3R)-(-)-2,3-Butanediol, 1,4-bis[bis[4-(trifluoromethyl)phenyl]phosphino]-, 1,4-acetonide; (R,R)-Tetra-CF3-DIPAMP; (R,R)-1,2-Bis[bis(4-trifluoromethylphenyl)phosphino]ethane acetonide; Chiral Bis(trifluoromethylphenyl)phosphine Ligand
EINECS	Contact for details

Quality Control

Our (+)-o-Isopropylidene-2,3-Dihydroxy-1,4-Bis[Bis(4-Trifluoromethylphenyl)Phosphino]Butane is manufactured under strict quality systems to ensure batch-to-batch consistency and high chiral purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C). This material is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain efficacy.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.