Description

Alanine, n-[(1,1-Dimethylethoxy)Carbonyl]-2-Methyl-, Hydrazide (9Ci) is a specialized Boc-protected amino acid derivative, specifically a hydrazide, designed for advanced synthetic applications. This compound is a critical building block in peptide synthesis and medicinal chemistry, offering a protected amine group and a reactive hydrazide functionality for selective coupling reactions. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions for the development of novel therapeutic agents and complex organic molecules. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency and purity for sensitive synthetic workflows.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected amino acid building block in solid-phase and solution-phase peptide synthesis, particularly where hydrazide chemistry is required.
• Medicinal Chemistry Research: Employed in the design and construction of chemical libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Bioconjugation: The reactive hydrazide group enables selective conjugation with aldehydes and ketones, useful for labeling proteins and other biomolecules.
• Organic Synthesis: Acts as a versatile reagent for introducing chiral centers and constructing heterocyclic compounds in complex organic molecule synthesis.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group provides orthogonal protection for amines in multi-step synthetic sequences.

Basic Information

Product Name	Alanine, n-[(1,1-Dimethylethoxy)Carbonyl]-2-Methyl-, Hydrazide (9Ci)
CAS No.	184002-61-7
Molecular Formula	C10H21N3O3
Molecular Weight	231.29 g/mol
Synonyms	Boc-2-Methylalanine hydrazide; N-(tert-Butoxycarbonyl)-2-methylalanine hydrazide; (2S)-2-[(tert-Butoxycarbonyl)amino]propanehydrazide; N-Boc-2-methylalanine hydrazide; tert-Butyl (1-(hydrazinecarbonyl)ethyl)carbamate; Alanine, N-[(1,1-dimethylethoxy)carbonyl]-2-methyl-, hydrazide; Boc-α-methylalanine hydrazide
EINECS	Contact for details

Quality Control

Our Alanine, n-[(1,1-Dimethylethoxy)Carbonyl]-2-Methyl-, Hydrazide is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR). We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.