Description

Fmoc-Ser(Tbu)-Cys(Psime,Mepro)-Oh CAS NO 183958-93-2 is a specialized, orthogonally protected dipeptide building block designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for enabling the precise and efficient assembly of complex peptides, particularly those requiring the selective formation of disulfide bonds. It is an essential raw material for pharmaceutical R&D, biotechnology, and academic research focused on developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the Fmoc/t-Bu strategy, facilitating the controlled incorporation of serine and cysteine residues.
• Disulfide Bridge Formation: The protected cysteine side chain (Cys(Psime,Mepro)) is specifically designed for the synthesis of peptides containing intramolecular or intermolecular disulfide bonds, crucial for the bioactivity of many therapeutic peptides.
• Pharmaceutical Research: Synthesis of peptide drug candidates, including hormone analogs, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation & Labeling: Used to introduce specific functional handles into peptide sequences for subsequent conjugation with reporter molecules, polymers, or other biomolecules.
• Chemical Biology Probes: Construction of peptides used as tools to study protein-protein interactions, enzyme activity, and cellular signaling pathways.
• Process Development: Serves as a high-purity intermediate in the scale-up and GMP manufacturing of peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Fmoc-Ser(Tbu)-Cys(Psime,Mepro)-Oh
CAS No.	183958-93-2
Molecular Formula	C31H40N2O7S2
Molecular Weight	616.79 g/mol
Synonyms	Fmoc-Ser(tBu)-Cys(Psime,Mepro)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-S-[(R)-2-methyl-1-(phenylsulfonyl)propyl]thio-L-cysteinyl-L-serine; Fmoc-Ser(O-t-Bu)-Cys(S-Psi(Me, Mpro))-OH; Fmoc-L-Serine(O-tert-butyl)-L-cysteine(S-(R)-2-methyl-1-(phenylsulfonyl)propyl)thioether; Fmoc-Ser(tBu)-Cys(S-Psi(Me,Mpro))-OH; Orthogonally protected Fmoc-Ser-Cys dipeptide
EINECS	Contact for details

Quality Control

Our Fmoc-Ser(Tbu)-Cys(Psime,Mepro)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-L configuration)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.