Description

Carbamic Acid, [(1R,4S)-4-(Hydroxymethyl)-2-Cyclobuten-1-Yl]-, 1,1- is a specialized chiral cyclobutene derivative of significant interest in advanced organic synthesis. This compound matters as a high-value pharmaceutical intermediate and building block for creating complex, biologically active molecules with precise stereochemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, particularly for antiviral, anticancer, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides with specific stereochemical requirements for enhanced activity.
• Fine Chemical Building Block: Serves as a versatile scaffold in academic and industrial research for constructing complex, strained-ring systems and natural product analogs.
• Chiral Catalyst/ Ligand Development: Employed in the preparation of novel chiral auxiliaries, ligands, or organocatalysts for asymmetric synthesis.
• Proteomics & Biochemistry Research: Potential use as a specialty reagent or molecular probe in biochemical studies due to its reactive carbamate and hydroxymethyl functionalities.

Basic Information

Product Name	Carbamic Acid, [(1R,4S)-4-(Hydroxymethyl)-2-Cyclobuten-1-Yl]-, 1,1-
CAS No.	183621-92-3
Molecular Formula	C6H9NO3
Molecular Weight	143.14 g/mol
Synonyms	(1R,4S)-4-(Hydroxymethyl)-2-cyclobuten-1-yl carbamate; 2-Cyclobuten-1-ylcarbamic acid, 4-(hydroxymethyl)-, (1R,4S)-; 1,1-Carbamic acid, [(1R,4S)-4-(hydroxymethyl)-2-cyclobuten-1-yl]-; (1R,4S)-rel-4-(Hydroxymethyl)-2-cyclobutenyl carbamate; Chiral Cyclobutene Carbamate; 4-Hydroxymethyl-2-cyclobutenylcarbamate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality control protocols suitable for pharmaceutical R&D. Each batch is characterized and tested to ensure identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as chiral purity (enantiomeric excess), chemical purity by HPLC, and residual solvent content. We support development with cGMP-compliant documentation practices upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and should be handled under an inert atmosphere if prolonged exposure is anticipated to prevent degradation. Keep container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.