Description

1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylicacid,7-Amino-3-Ethyl-8-Oxo-,(6R- is a high-purity, advanced pharmaceutical intermediate belonging to the β-lactam class of compounds. This compound is of significant commercial importance as a key building block in the synthesis of novel cephalosporin antibiotics, enabling the development of next-generation therapeutics. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in antibiotic production.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of advanced cephalosporin and carbapenem antibiotic candidates.
• Antibiotic Research & Development: Serves as a core scaffold for medicinal chemists exploring new antibacterial agents with improved efficacy and resistance profiles.
• Fine Chemical Synthesis: Used in multi-step organic synthesis to construct complex, biologically active molecules targeting bacterial infections.
• Contract Manufacturing: Supplied to CDMOs for the scale-up and commercial production of proprietary antibiotic formulations.
• Academic Research: Utilized in university and institutional labs for studying β-lactam chemistry, mechanism of action, and structure-activity relationships (SAR).
• Process Chemistry Development: Employed in optimizing synthetic routes for more efficient and cost-effective production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylicacid,7-Amino-3-Ethyl-8-Oxo-,(6R-
CAS No.	183383-80-4
Molecular Formula	C10H14N2O3
Molecular Weight	210.23 g/mol
Synonyms	(6R)-7-Amino-3-ethyl-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-Amino-3-ethyl-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6R-); 3-Ethyl-7-amino-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Advanced Cephalosporin Intermediate; β-lactam Intermediate AZB-4.2.0; Ethyl-substituted azabicyclo β-lactam; 1-Azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. The material is manufactured under controlled conditions with purity typically exceeding 98.0% (by HPLC). Comprehensive analytical testing, including chiral purity verification, is performed. A Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.