Description

5-Oxa-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylicacid,7-Amino-3-Fluoro-8-Oxo-,(6R-Trans)-(9Ci) is a high-purity, advanced pharmaceutical intermediate belonging to the bicyclic β-lactam class of compounds. This compound is of significant commercial importance as a key synthetic precursor in the development of novel, next-generation antibiotics and β-lactamase inhibitors. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the synthesis of specialized antimicrobial agents to address evolving bacterial resistance.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel cephalosporin and carbapenem antibiotic candidates.
• Antimicrobial Research: Used in medicinal chemistry programs focused on developing new agents against multi-drug resistant (MDR) bacterial strains.
• β-Lactamase Inhibitor Development: Acts as a core structure for creating new compounds designed to inhibit bacterial enzymes that degrade conventional β-lactam antibiotics.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of advanced antibiotic APIs.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory filing purposes in pharmaceutical development.

Basic Information

Product Name	5-Oxa-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylicacid,7-Amino-3-Fluoro-8-Oxo-,(6R-Trans)-(9Ci)
CAS No.	183383-76-8
Molecular Formula	C7H7FN2O4
Molecular Weight	202.14 g/mol
Synonyms	(6R-trans)-7-Amino-3-fluoro-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-Amino-3-fluoro-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, (6R-trans)-; 3-Fluoro-7-amino-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Fluorinated bicyclic β-lactam intermediate; Advanced cephalosporin precursor
EINECS	Contact for details

Quality Control

Our 5-Oxa-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylicacid,7-Amino-3-Fluoro-8-Oxo-,(6R-Trans)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the stringent requirements for pharmaceutical R&D and process development. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.