Description

β-Amyloid (35-42) CAS NO 183292-41-3 is a synthetic peptide fragment corresponding to amino acids 35-42 of the human amyloid-beta protein, a key component in the study of neurodegenerative diseases. This high-purity research chemical is critical for advancing our understanding of amyloid plaque formation and neurotoxicity mechanisms. It is an essential tool for pharmaceutical R&D, academic research, and diagnostic development focused on Alzheimer's disease and related conditions.

Application

• Neuroscience Research: Fundamental studies on amyloid-beta aggregation kinetics, oligomer formation, and fibrillogenesis.
• Drug Discovery & Screening: Used as a target or reference standard in high-throughput assays to identify and validate potential therapeutic compounds that inhibit aggregation or promote clearance.
• Biomarker & Diagnostic Development: Serves as a critical antigen or calibrator in the development of immunoassays (ELISA, Western Blot) and biosensors for detecting amyloid-beta peptides in biological samples.
• Toxicology Studies: Investigation of the peptide's cytotoxic effects on neuronal cell cultures to model disease pathology and assess neuroprotective agents.
• Antibody Production & Characterization: Used as an immunogen to generate specific antibodies or to test antibody affinity and specificity for diagnostic and therapeutic applications.
• Structural Biology: Provides material for NMR, X-ray crystallography, and other biophysical techniques to elucidate the three-dimensional structure of amyloid-beta fragments.

Basic Information

Product Name	β-Amyloid (35-42)
CAS No.	183292-41-3
Molecular Formula	C41H68N12O13
Molecular Weight	913.05 g/mol
Synonyms	Amyloid β-Protein (35-42); Aβ35-42; β-Amyloid Peptide (35-42); Amyloid β (35-42); Aβ (35-42); H-Gly-Gly-Val-Val-Ile-Ala-Ile-Leu-OH; Amyloid β-Protein Fragment 35-42
EINECS	Contact for details

Quality Control

Every batch of β-Amyloid (35-42) is manufactured under stringent conditions and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Our quality commitment includes adherence to cGMP guidelines for research-grade peptides. A detailed Certificate of Analysis (COA) is provided with each shipment, reporting key parameters such as purity (HPLC), molecular weight confirmation (MS), and peptide content.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Molecular Weight	913.05 ± 2 Da (MALDI-TOF/MS)
Solubility	Soluble in DMSO, Acetic Acid; Sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.