Description

(S)-Isothipendyl CAS NO 183287-72-1 is the single enantiomer of the classical antihistamine isothipendyl, representing a high-purity chiral building block of significant interest in advanced pharmaceutical research and development. This compound matters for its role in enabling stereoselective studies and the creation of novel, targeted therapeutic agents with potentially improved efficacy and reduced side-effect profiles. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries working on next-generation central nervous system (CNS) and allergy medications.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the synthesis of novel histamine H1-receptor antagonists.
• Stereochemical Research: Used as a reference standard in pharmacological studies to investigate the enantioselective binding and activity of isothipendyl derivatives.
• Active Pharmaceutical Ingredient (API) Development: Employed in the development and scale-up of enantiomerically pure active substances for clinical trials.
• Biochemical Tool Compound: Utilized in vitro and in vivo to study the specific physiological effects mediated by the (S)-enantiomer.
• Process Chemistry: Acts as a model compound for developing and optimizing asymmetric synthesis and chiral separation techniques.
• Quality Control & Analytical Standards: Provides a high-purity standard for HPLC, LC-MS, and NMR methods to ensure the quality and enantiomeric excess of related compounds.

Basic Information

Product Name	(S)-Isothipendyl
CAS No.	183287-72-1
Molecular Formula	C16H19N3S
Molecular Weight	285.41 g/mol
Synonyms	(S)-Isothipendyl; (S)-10-(2-Dimethylamino-1-propyl)-10H-pyrido[3,2-b][1,4]benzothiazine; (-)-Isothipendyl; Levoisothipendyl; (S)-10-(2-Dimethylaminopropyl)pyrido[3,2-b][1,4]benzothiazine; UNII-9S7986KN5B; (S)-Form of Isothipendyl; Dexisothipendyl (Note: sometimes used for the opposite enantiomer, verify context)
EINECS	Contact for details

Quality Control

Our (S)-Isothipendyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by assay and chiral HPLC), and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.