Description

1-Trifluoromethylacetylbenzotriazole is a high-purity, specialized benzotriazole derivative featuring a reactive trifluoromethylacetyl group. This compound matters as a versatile and critical building block in advanced organic synthesis, enabling the introduction of the trifluoromethyl moiety to enhance the metabolic stability and lipophilicity of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the CF3 group improves biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, coatings, and liquid crystals with unique optical or electronic properties.
• Fluorine Chemistry Research: An essential reagent in academic and industrial laboratories focused on organofluorine chemistry and methodology development.
• Peptide Modification: Employed to incorporate fluorinated groups into peptides and peptidomimetics, altering their binding affinity and pharmacokinetic profile.

Basic Information

Product Name	1-Trifluoromethylacetylbenzotriazole
CAS No.	183266-61-7
Molecular Formula	C9H5F3N3O
Molecular Weight	228.15 g/mol
Synonyms	1-(2,2,2-Trifluoroacetyl)-1H-benzotriazole; 1H-Benzotriazole, 1-(2,2,2-trifluoroacetyl)-; 2,2,2-Trifluoro-1-(1H-1,2,3-benzotriazol-1-yl)ethanone; Trifluoroacetybenzotriazole; N-Trifluoroacetylbenzotriazole; BTATFA; 1-TFAB; 1-Trifluoroacetylbenzotriazole
EINECS	Contact for details

Quality Control

Our 1-Trifluoromethylacetylbenzotriazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.