Description

Acetamide, N-[4-(Trimethylsilyl)-3-butynyl]- (9CI) is a specialized organosilicon building block featuring both an amide and a terminal alkyne functional group protected by a trimethylsilyl (TMS) moiety. This unique molecular architecture makes it a valuable intermediate for advanced organic synthesis, particularly in the construction of complex molecules and functional materials. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for applications such as click chemistry, peptide modification, and the development of novel silicon-containing compounds.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), leveraging its amide and protected alkyne for Huisgen cycloaddition (click chemistry) reactions.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators that incorporate silicon to enhance stability and bioavailability.
• Material Science: Acts as a monomer or cross-linking agent in the production of specialty polymers, silicones, and advanced functional materials with tailored properties.
• Chemical Biology & Bioconjugation: Employed for labeling and modifying biomolecules like peptides, proteins, and nucleic acids via its reactive alkyne handle.
• Organic Synthesis Building Block: Provides a protected alkyne source for Sonogashira coupling and other palladium-catalyzed cross-coupling reactions to create complex molecular architectures.
• Ligand & Catalyst Development: Used in the synthesis of novel ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	Acetamide, N-[4-(Trimethylsilyl)-3-butynyl]- (9CI)
CAS No.	183208-72-2
Molecular Formula	C9H17NOSi
Molecular Weight	183.33 g/mol
Synonyms	N-[4-(Trimethylsilyl)-3-butyn-1-yl]acetamide; 4-(Trimethylsilyl)-3-butynylacetamide; 3-Butynamide, N-[4-(trimethylsilyl)-]-; Acetamide, N-[4-(trimethylsilyl)-3-butynyl]-; TMS-Protected Alkyne Acetamide; (4-Acetamidobut-2-yn-1-yl)trimethylsilane
EINECS	Contact for details

Quality Control

Our Acetamide, N-[4-(Trimethylsilyl)-3-butynyl]- (9CI) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 95% (Typical: 97-99%)
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.