Description

Guanylin (Human) CAS NO 183200-12-6 is a synthetic peptide hormone that plays a crucial role in regulating intestinal fluid and electrolyte homeostasis. This high-purity compound is essential for advanced biochemical research and pharmaceutical development. It is primarily utilized by researchers in endocrinology, gastroenterology, and drug discovery for studying receptor binding, signal transduction pathways, and as a reference standard.

Application

• Biomedical Research: Fundamental studies on guanylate cyclase-C (GC-C) receptor activation and intracellular cGMP signaling pathways.
• Drug Discovery & Development: Serving as a critical reference standard and lead compound for developing novel therapeutics targeting secretory diarrheas, constipation, and colorectal cancer.
• In Vitro & Ex Vivo Assays: Used in cell-based assays and tissue bath experiments to investigate intestinal secretion and epithelial function.
• Pharmacology Studies: Evaluation of peptide stability, metabolism, and structure-activity relationships (SAR).
• Diagnostic Tool Development: Potential use in developing assays to study GC-C receptor expression and function in disease states.

Basic Information

Product Name	Guanylin (Human)
CAS No.	183200-12-6
Molecular Formula	C78H122N24O26S4
Molecular Weight	1876.2 g/mol
Synonyms	Guanylin-15; Guanylin (1-15), human; Guanylin Peptide; H-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH (disulfide bridges: Cys3-Cys12, Cys6-Cys15); ST peptide; Ligand for Guanylyl Cyclase C; GC-C agonist
EINECS	Contact for details

Quality Control

Our Guanylin (Human) is manufactured under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, Mass Spectrometry (MS) for identity confirmation, and Amino Acid Analysis (AAA). Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by AAA)
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.