Description

(Arg15,Asp16,25,Pro18,21,23,Val22,Ile24)-Amyloid β-Protein (15-25) CAS NO 182912-63-6 is a synthetic peptide fragment derived from the amyloid β-protein sequence, specifically engineered with key amino acid substitutions. This modified peptide is a critical research tool for studying the aggregation mechanisms, structural stability, and neurotoxic effects associated with amyloid-related pathologies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neurodegenerative disease research, drug discovery, and diagnostic development.

Application

• Neuroscience Research: Fundamental studies on amyloid beta aggregation kinetics, fibril formation, and oligomer toxicity.
• Drug Discovery Screening: Serving as a target or reference compound in high-throughput assays to identify potential inhibitors of amyloid aggregation.
• Biophysical Studies: Investigation of peptide structure, stability, and interactions using techniques like NMR, CD spectroscopy, and X-ray crystallography.
• Antibody & Diagnostic Development: Used as an antigen for generating and characterizing antibodies specific to modified amyloid beta epitopes.
• Toxicity & Cell Biology Assays: Evaluating the cellular and synaptic toxicity of specific amyloid beta conformers in neuronal cell cultures.
• Biomaterial Research: Studying the properties of peptide-based nanomaterials and self-assembling structures.

Basic Information

Product Name	(Arg15,Asp16,25,Pro18,21,23,Val22,Ile24)-Amyloid β-Protein (15-25)
CAS No.	182912-63-6
Molecular Formula	C58H94N20O19
Molecular Weight	1359.5 g/mol
Synonyms	Abeta (15-25) mutant peptide; Aβ(15-25) [R15E, P18A, P21A, V22A, P23A, I24A, D25A]; Amyloid β-Protein (15-25) fragment, modified; H-Arg-Val-His-His-Gln-Lys-Leu-Val-Asp-Ala-NH2 (modified sequence); Research peptide 182912-63-6; Custom amyloid beta analogue; Neurodegenerative disease research peptide
EINECS	Contact for details

Quality Control

Every batch of our research-grade peptides is produced under strict quality management and undergoes comprehensive analytical characterization. Standard quality control includes HPLC for purity verification and Mass Spectrometry (MS) for identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data on purity, amino acid analysis, and peptide content. Our quality systems are designed to meet the exacting standards required for reproducible biomedical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.