Description

Fmoc-L-Dap-Otbu*Hcl CAS NO 182618-30-0 is a protected derivative of the non-proteinogenic amino acid L-2,3-diaminopropionic acid (L-Dap), featuring Fmoc (9-fluorenylmethoxycarbonyl) and tert-butyl ester (OtBu) protecting groups. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of a diamino acid side chain for constructing complex peptide architectures. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-based drugs, diagnostic agents, and biochemical tools where precise sequence control and side-chain functionality are paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the automated synthesis of peptides containing L-2,3-diaminopropionic acid residues.
• Pharmaceutical Intermediates: Serves as a crucial intermediate in the research and development of novel therapeutic peptides, including antimicrobial peptides (AMPs) and hormone analogs.
• Bioconjugation and Linker Chemistry: Used to introduce a free amino group (after deprotection) for site-specific conjugation with labels, tags, or other biomolecules.
• Peptidomimetic Design: Facilitates the creation of modified peptide structures (peptidomimetics) with enhanced stability, bioavailability, or specific biological activity.
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms by incorporating specific, modifiable amino acid analogs into peptide probes.
• Combinatorial Library Synthesis: A valuable component for generating diverse peptide libraries used in high-throughput screening for drug discovery.

Basic Information

Product Name	Fmoc-L-Dap-Otbu*Hcl
CAS No.	182618-30-0
Molecular Formula	C23H28N2O4 • HCl
Molecular Weight	440.94 g/mol
Synonyms	Fmoc-L-2,3-diaminopropionic acid tert-butyl ester hydrochloride; N-α-Fmoc-L-2,3-diaminopropionic acid tert-butyl ester hydrochloride; Fmoc-L-Dap(OtBu)-OH • HCl; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)propanoic acid hydrochloride; Fmoc-L-β-diaminopropionate(OtBu)-OH • HCl; Nα-Fmoc-Nβ-Boc-L-α,β-diaminopropionic acid; Fmoc-Dap(Boc)-OH • HCl (common abbreviation)
EINECS	Contact for details

Quality Control

Our Fmoc-L-Dap-Otbu*Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR/IR for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducible performance and supply chain reliability for your critical R&D and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.