Description

Raloxifene 4'-Glucuronide is a major, pharmacologically relevant metabolite of the selective estrogen receptor modulator (SERM) Raloxifene. This compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics (PK/ADME), and bioanalytical method validation. It is an essential reference standard for laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors requiring high-purity materials for analytical and developmental work.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for quantitative and qualitative analysis in drug development.
• Metabolite Identification & Profiling: Crucial for in vitro and in vivo ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the metabolic fate of Raloxifene.
• Bioanalytical Method Development: Used as a calibration standard in LC-MS/MS, HPLC, and other chromatographic assays for accurate quantification in biological matrices.
• Pharmacokinetic (PK) Studies: Enables precise measurement of metabolite levels to establish PK/PD (Pharmacodynamics) relationships.
• Impurity Characterization: Serves as a known impurity or degradation product standard for drug substance and product quality control.
• Regulatory Submissions: Supports investigational new drug (IND) and new drug application (NDA) filings by providing definitive metabolite data.

Basic Information

Product Name	Raloxifene 4'-Glucuronide
CAS No.	182507-22-8
Molecular Formula	C33H35NO11S
Molecular Weight	653.70 g/mol
Synonyms	Raloxifene 4'-β-D-Glucuronide; Raloxifene Glucuronide; 6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl 4-[2-(1-piperidinyl)ethoxy]phenyl 4'-O-β-D-Glucopyranuronosyl Methanone; LY353381 Glucuronide; Keoxifene Glucuronide
EINECS	Contact for details

Quality Control

Our Raloxifene 4'-Glucuronide is manufactured and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, LC-MS identification, and NMR confirmation, to ensure identity, potency, and purity meet the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.