Description

Raloxifene 6,4Bis-B-D-Glucuronide is a key glucuronide metabolite of the selective estrogen receptor modulator (SERM) Raloxifene. This compound is of significant importance in pharmaceutical research and development for studying the metabolic pathways, pharmacokinetics, and bioavailability of Raloxifene-based therapies. It serves as a critical reference standard and intermediate for analytical laboratories, pharmaceutical manufacturers, and research institutions focused on women's health, osteoporosis treatment, and oncology.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for the quantitative and qualitative analysis of Raloxifene and its metabolites in biological matrices via HPLC, LC-MS, and other analytical techniques.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Essential for investigating the Phase II conjugation metabolism, clearance mechanisms, and overall ADME (Absorption, Distribution, Metabolism, Excretion) profile of Raloxifene.
• Bioanalytical Method Development: Critical for developing and validating robust analytical methods to monitor Raloxifene glucuronide levels in clinical and pre-clinical studies.
• Impurity Profiling: Employed to identify and quantify related substances and degradation products in Raloxifene active pharmaceutical ingredient (API) and finished dosage forms to ensure product safety and compliance.
• Research on SERM Mechanisms: Used in biochemical and pharmacological research to understand the role of glucuronidation in modulating the tissue-specific activity and side-effect profile of SERMs.

Basic Information

Product Name	Raloxifene 6,4Bis-B-D-Glucuronide
CAS No.	182507-20-6
Molecular Formula	C39H44O16S2
Molecular Weight	832.88 g/mol
Synonyms	Raloxifene Bisglucuronide; Raloxifene 6,4-Bis(β-D-glucuronide); Raloxifene Diglucuronide; 6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl 4-[2-(1-piperidinyl)ethoxy]phenyl bis(β-D-glucopyranosiduronate) methanesulfonate; LY353381.HCl bisglucuronide; Keoxifene bisglucuronide
EINECS	Contact for details

Quality Control

Our Raloxifene 6,4Bis-B-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC purity analysis, LC-MS identification, and residual solvent screening, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.