Description

Benzonitrile, 3-Amino-2-Hydroxy-6-Methyl- (9Ci) CAS NO 182499-93-0 is a multifunctional aromatic nitrile derivative characterized by its amino and hydroxy substituents, making it a valuable synthon for complex organic synthesis. This compound is essential for research and development chemists seeking to build advanced molecular architectures, particularly in the pharmaceutical and agrochemical sectors. Its unique substitution pattern offers precise control over regiochemistry and reactivity, making it a critical intermediate for producing active pharmaceutical ingredients (APIs), fine chemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, leveraging its aromatic core for bioactivity.
• Dye and Pigment Manufacturing: Serves as a precursor for azo dyes and other complex colorants due to its reactive amino and cyano groups.
• Ligand and Catalyst Development: The amino and hydroxy groups make it suitable for creating chelating ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Polymer Chemistry: Acts as a monomer or cross-linking agent for specialty polymers, including high-performance resins and engineering plastics.
• Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new chemical reactions and synthesizing complex heterocyclic compounds.

Basic Information

Product Name	Benzonitrile, 3-Amino-2-Hydroxy-6-Methyl- (9Ci)
CAS No.	182499-93-0
Molecular Formula	C8H8N2O
Molecular Weight	148.16 g/mol
Synonyms	3-Amino-2-hydroxy-6-methylbenzonitrile; 2-Hydroxy-3-amino-6-methylbenzonitrile; 6-Methyl-3-amino-2-hydroxybenzonitrile; 2-Cyano-6-methyl-3-aminophenol; 3-Amino-2-hydroxy-p-tolunitrile; 2-Hydroxy-3-amino-p-tolunitrile; 3-Amino-6-methyl-2-hydroxybenzonitrile; 2-Hydroxy-3-amino-6-methylbenzenecarbonitrile
EINECS	Contact for details

Quality Control

Our production of Benzonitrile, 3-Amino-2-Hydroxy-6-Methyl- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and purity for critical applications. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, IR and NMR for structural confirmation, and loss on drying for moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We operate under a quality management system and can supply material compliant with cGMP standards for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.