Description

n-(Piperidin-4-Yl)-4'-(Trifluoromethyl)-[1,1'-Biphenyl]-2-Carboxamide CAS NO 182439-41-4 is a high-purity, advanced pharmaceutical intermediate characterized by its distinct biphenyl and piperidine scaffold. This compound matters for its critical role as a key building block in the synthesis of novel, targeted therapeutic agents, offering researchers a reliable and well-defined starting material. It is primarily needed by pharmaceutical R&D organizations and fine chemical manufacturers engaged in developing small molecule drugs, particularly within oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of potential drug candidates, especially kinase inhibitors and receptor modulators.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical entities.
• Biochemical Tool Compound: Employed in vitro and in vivo to study biological pathways and validate novel drug targets.
• Custom Synthesis & Contract Manufacturing: A key material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client research programs.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and pharmacology.

Basic Information

Product Name	n-(Piperidin-4-Yl)-4'-(Trifluoromethyl)-[1,1'-Biphenyl]-2-Carboxamide
CAS No.	182439-41-4
Molecular Formula	C20H19F3N2O
Molecular Weight	360.38 g/mol
Synonyms	4'-(Trifluoromethyl)-[1,1'-biphenyl]-2-carboxylic acid piperidin-4-ylamide; 4'-Trifluoromethylbiphenyl-2-carboxylic acid (4-piperidyl)amide; N-(4-Piperidinyl)-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide; Biphenyl-2-carboxamide, N-(4-piperidinyl)-4'-(trifluoromethyl)-; 182439-41-4; 4-Piperidinamine, N-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]-
EINECS	Contact for details

Quality Control

Our n-(Piperidin-4-Yl)-4'-(Trifluoromethyl)-[1,1'-Biphenyl]-2-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure compliance with research-grade specifications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.